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amino esters : ウィキペディア英語版
amino esters
Amino esters are a class of local anesthetics.
==Structure==
Structurally, local anesthetics consist of three molecular components:
* a lipophilic part
* an intermediate aliphatic chain
* a hydrophilic (amine) part
The chemical linkage between the lipophilic part and the intermediate chain can be of the amide-type or the ester-type, and is the general basis for the current classification of local anesthetics.
Amino esters, in reference to anesthetic agents, are rapidly metabolized in the plasma by butyrlcholinesterase to para-aminobenzoic acid derivatives, then excreted in the urine. This suggests their very short half lives. Allergy is more likely to occur with ester-type agents, as opposed to amide-type.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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